Gut Cells That Can Combat IBD
TOPLINE Loss-of-function mutations in G protein-coupled receptor 15 (GPR15) were associated with early-onset inflammatory bowel disease (IBD) through impaired homing of regulatory CD8+ T cells to the colonic mucosa. These GPR15-guided CD8+ regulatory T cells (CD8+ TIGR) suppressed intestinal inflammation by killing activated macrophages, and their deficiency led to macrophage accumulation and severe colitis. METHODOLOGY…
